Our product development is grounded in scientific research and clinical evaluation. Every study below is summarised in plain language, labelled by design. Formula details are kept confidential, full papers are available on request.
Two claims you see on packaging, two very different levels of proof. Here is what each one means.
We label every study by its design so you can judge its strength at a glance. More filled bars mean a more rigorous design.
Measured outcomes from published studies of our formulas, charted from the data reported in each paper.
No studies match your search.
Melanin index decreased and measured skin brightness increased after six weeks of the combination serum and cream.
Hero activeContact us to find out the hero active ↗Aesthetic Cosmetology and Medicine. 2025; ███████
Measured brightness increased and pigmented spots decreased during an eight-week serum-and-cream regimen.
Hero activeContact us to find out the hero active ↗Journal of Pakistan Association of Dermatologists. 2024; ███████
Treated cheek areas showed improved brightness and melasma severity scores. Melanin-index changes were not statistically significant.
Hero activeContact us to find out the hero active ↗Azerbaijan Medical Journal. 2022; ██████████
The layering regimen reduced MASI scores earlier, from week 4, while the Kligman group improved by week 8. The difference between groups was significant at both time points.
Hero activeContact us to find out the hero active ↗Jurnal Health Sains. 2021; ██████████
The combination group had a lower melanin index and a higher brightness score than placebo at eight weeks.
Hero activeContact us to find out the hero active ↗International Journal of Dermatology. 2021; ██████████
Melasma severity and UV-spot measurements decreased. Polarised-light spot measurements did not change significantly.
Hero activeContact us to find out the hero active ↗Hong Kong Journal of Dermatology & Venereology. 2020; █████
Melanin and spot scores improved in the serum group, but differences versus placebo were not statistically significant.
Hero activeContact us to find out the hero active ↗Bali Dermatology and Venereology Journal. 2020; ███████
Both the combination serum and 4% hydroquinone increased measured skin brightness during the four-week study.
Hero activeContact us to find out the hero active ↗International Journal of Medical Reviews and Case Reports. 2018; ██████
The authors reported significant reductions in body weight and improved metabolic parameters versus placebo.
Hero activeContact us to find out the hero active ↗Lipids in Health and Disease. 2009; ████
Examined how closely laboratory SPF measurements correlate with measurements on human skin.
Journal of Food and Drug Analysis. 2003; ████████
All measures improved significantly over eight weeks: lower mMASI scores and fewer pigmented spots, brighter skin (L* 46.8 → 50.9) and a lower melanin index (359 → 311).
Hero activeContact us to find out the hero active ↗Journal of Pakistan Association of Dermatologists. 2024; ████████
The treatment group improved significantly more than the control group in clinical scores, quality of life and instrumental melanin and erythema readings at week 16.
Hero activeContact us to find out the hero active ↗Research Square preprint, 2023. doi:10.21203/rs.3.rs-2628737/v1
Six products exceeded the US FDA limit of 1 ppm, three above 400 ppm, a reminder of why regulated, tested brightening actives matter.
Journal of Health and Pollution. 2020; ████████
Garcinia produced a small, statistically significant short-term weight loss versus placebo (about 0.9 kg); the authors call for more rigorous trials.
Journal of Obesity. 2011; ███████
Ashwagandha had a small but significant benefit for overall sleep, stronger in adults with insomnia, at ≥600 mg a day for ≥8 weeks, and improved alertness and anxiety.
PLOS ONE. 2021; █████████
The authors report that the yam extract enhanced cognitive function in healthy adults compared with placebo.
Nutrients. 2017; ███████
Real-life data from these patients support the safety of nattokinase alongside standard treatment.
Nutrients. 2021; ███████
Only the 5000 IU group raised blood vitamin D significantly, and it recovered faster from cough and loss of taste.
Nutrients. 2021; ███████
Summarises where supplementation shows clear benefit, especially in people with low vitamin D status, and where evidence remains uncertain.
Nature Reviews Endocrinology. 2022; ██████
The three nutrients act together to support immunity and tissue barriers, making them relevant candidates for immune-support formulas.
Frontiers in Nutrition. 2020; █████
Moringa is rich in essential amino acids, carotenoids and other nutraceutical compounds, supporting its use as a nutritional supplement ingredient.
Asian Pacific Journal of Cancer Prevention. 2014; ██████████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
For selected formulations, we can arrange clinical studies with Indonesian participants. A typical study moves through these stages:
A clinical study with the Department of Dermatology & Venereology, Faculty of Medicine, Universitas Hasanuddin, instrumental skin measurements on Indonesian volunteers.
Doctors who work with our formulas talk about what they see in practice.
Cosmetic science and anti-aging medicine, for clinicians and product teams alike.
Share an idea, a sample or a question. We’ll help you work out the next step.
A leave-on █████████ and █████████ regimen, used as a serum and cream.
Melanin index decreased and measured skin brightness increased after six weeks of the combination serum and cream.
Participants know what they use; results are compared with their own starting point.
Aesthetic Cosmetology and Medicine. 2025; ███████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
████████, ██████████, ██████████ and ████████ applied in layers; measured by chromameter and Janus-III skin imaging.
Measured brightness increased and pigmented spots decreased during an eight-week serum-and-cream regimen.
Participants know what they use; results are compared with their own starting point.
Journal of Pakistan Association of Dermatologists. 2024; ███████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
A four-active serum applied to the cheeks, with the untreated forehead used as a comparison.
Treated cheek areas showed improved brightness and melasma severity scores. Melanin-index changes were not statistically significant.
Results are compared against an untreated area or a reference treatment.
Azerbaijan Medical Journal. 2022; ██████████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
A layered regimen of ████████ cream and ██████████, compared with a modified Kligman formula (4% hydroquinone, tretinoin and a corticosteroid) in patients with melasma.
The layering regimen reduced MASI scores earlier, from week 4, while the Kligman group improved by week 8. The difference between groups was significant at both time points.
Randomised, and neither participants nor researchers know who receives the product, the most rigorous design.
Jurnal Health Sains. 2021; ██████████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
A ███████ and vitamin C serum used together with oral ███████ capsules, compared with placebo.
The combination group had a lower melanin index and a higher brightness score than placebo at eight weeks.
Randomised, and neither participants nor researchers know who receives the product, the most rigorous design.
International Journal of Dermatology. 2021; ██████████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
A serum and cream with █████████, ██████████, ███████ and ████████, applied in layers at multiple centres.
Melasma severity and UV-spot measurements decreased. Polarised-light spot measurements did not change significantly.
Participants know what they use; results are compared with their own starting point.
Hong Kong Journal of Dermatology & Venereology. 2020; █████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
A serum with ██████████, ███████ and ██████████, compared with placebo.
Melanin and spot scores improved in the serum group, but differences versus placebo were not statistically significant.
Participants are randomly assigned to the product or a placebo.
Bali Dermatology and Venereology Journal. 2020; ███████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
A combination serum applied to one forearm and 4% hydroquinone to the other, in the same participants.
Both the combination serum and 4% hydroquinone increased measured skin brightness during the four-week study.
Results are compared against an untreated area or a reference treatment.
International Journal of Medical Reviews and Case Reports. 2018; ██████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
A seed extract of ██████████, compared with placebo in overweight adults.
The authors reported significant reductions in body weight and improved metabolic parameters versus placebo.
Randomised, and neither participants nor researchers know who receives the product, the most rigorous design.
Lipids in Health and Disease. 2009; ████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“Correlation of In Vivo and In Vitro Measurements of Sun Protection Factor”
In-vivo (on skin) and in-vitro (laboratory) methods for measuring sun protection factor.
Examined how closely laboratory SPF measurements correlate with measurements on human skin.
Laboratory measurements or comparisons of testing methods, useful for technical validation.
Journal of Food and Drug Analysis. 2003; ████████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
Each night, ████████ serum for 15 minutes followed by ██████████ cream, in melasma patients at two hospitals in Makassar.
All measures improved significantly over eight weeks: lower mMASI scores and fewer pigmented spots, brighter skin (L* 46.8 → 50.9) and a lower melanin index (359 → 311).
Participants know what they use; results are compared with their own starting point.
Journal of Pakistan Association of Dermatologists. 2024; ████████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
A ██████████ versus a vehicle (inactive base) in patients with post-inflammatory hyperpigmentation.
The treatment group improved significantly more than the control group in clinical scores, quality of life and instrumental melanin and erythema readings at week 16.
Randomised, and neither participants nor researchers know who receives the product, the most rigorous design.
Research Square preprint, 2023. doi:10.21203/rs.3.rs-2628737/v1
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“Mercury Exposure Associated with Use of Skin Lightening Products in Jamaica”
Sixty skin-lightening products bought across Jamaica, screened for mercury by X-ray fluorescence and atomic absorption spectroscopy.
Six products exceeded the US FDA limit of 1 ppm, three above 400 ppm, a reminder of why regulated, tested brightening actives matter.
Laboratory measurements or comparisons of testing methods, useful for technical validation.
Journal of Health and Pollution. 2020; ████████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials”
A pooled analysis of randomised trials comparing Garcinia extract (hydroxycitric acid) with placebo.
Garcinia produced a small, statistically significant short-term weight loss versus placebo (about 0.9 kg); the authors call for more rigorous trials.
Pools the results of several randomised trials to estimate an overall effect.
Journal of Obesity. 2011; ███████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis”
A pooled analysis of randomised, placebo-controlled trials of Ashwagandha extract on sleep in adults.
Ashwagandha had a small but significant benefit for overall sleep, stronger in adults with insomnia, at ≥600 mg a day for ≥8 weeks, and improved alertness and anxiety.
Pools the results of several randomised trials to estimate an overall effect.
PLOS ONE. 2021; █████████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults”
Soft capsules of diosgenin-rich yam extract versus placebo for 12 weeks each, in healthy adults aged 20–81, in a crossover design.
The authors report that the yam extract enhanced cognitive function in healthy adults compared with placebo.
Randomised, and neither participants nor researchers know who receives the product, the most rigorous design.
Nutrients. 2017; ███████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“Data Recorded in Real Life Support the Safety of Nattokinase in Patients with Vascular Diseases”
Nattokinase 100 mg a day, alone or with standard anticoagulant care, in vascular surgery patients followed in routine practice.
Real-life data from these patients support the safety of nattokinase alongside standard treatment.
Follows patients in routine practice rather than assigning treatments at random.
Nutrients. 2021; ███████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial”
Vitamin D3 at 5000 IU versus 1000 IU a day for two weeks, in patients with mild to moderate COVID-19 and low vitamin D.
Only the 5000 IU group raised blood vitamin D significantly, and it recovered faster from cough and loss of taste.
Participants are randomly assigned to the product or a placebo.
Nutrients. 2021; ███████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“The health effects of vitamin D supplementation: evidence from human studies”
An expert review of randomised trials and genetic studies on the skeletal and extra-skeletal effects of vitamin D.
Summarises where supplementation shows clear benefit, especially in people with low vitamin D status, and where evidence remains uncertain.
Summarises published research on a topic; it does not collect new data.
Nature Reviews Endocrinology. 2022; ██████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“Zinc, Vitamin D and Vitamin C: Perspectives for COVID-19 With a Focus on Physical Tissue Barrier Integrity”
A review of how zinc and vitamins C and D support the immune response and the physical tissue barriers against viral infection.
The three nutrients act together to support immunity and tissue barriers, making them relevant candidates for immune-support formulas.
Summarises published research on a topic; it does not collect new data.
Frontiers in Nutrition. 2020; █████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
“Health Benefits of Moringa oleifera”
A review of the nutritional and medicinal properties of Moringa oleifera leaves, seeds and other parts.
Moringa is rich in essential amino acids, carotenoids and other nutraceutical compounds, supporting its use as a nutritional supplement ingredient.
Summarises published research on a topic; it does not collect new data.
Asian Pacific Journal of Cancer Prevention. 2014; ██████████
Publications provide research context. Finished-product claims depend on product-specific testing and applicable regulatory requirements.
